Liposomal clodronate is a new form of treatment for autoimmune diseases as well as prevention of transplant rejection. It is used to deplete macrophages, thus suppressing immune activity which at present may be heightened for people having an autoimmune disease or those who just came out from transplant surgery.
The results concerning clodronate liposome therapy has been quite fascinating. It showed a strong performance in suppressing the immune system which gave a new hope for rejected transplant patients as well as those that have been suffering on the worst stage of their autoimmune disease. Additionally, such therapy also showed positive results in conjunction with cancer drugs.
Originally clodronic acid is biphosphonate, anti-osteoporotic drug. It was approved for the treatment and prevention of osteoporosis particularly to women and hyperparathyroidism, hypercalcemia and vertebral fracture to men. It was noticed that clodronic acid has a potent analgesic and anti inflammatory effects as it significantly reduced important inflammatory markers.
Inflammatory marker as the name implies is a sign that inflammation is currently going on. Famous inflammatory markers includes interleukin 6,8 and 1 as well as TNF-alfa. However, these markers are only a tiny part of the immune system. Indeed, the immune system consists of thousands of cells all of which has its own tiny role.
Clodronic acid liposome therapy, targets the macrophages to efficiently halt the attack of healthy cells. Suppressing your macrophages will slow down inflammation thus decreasing the pace of disease progression. Some autoimmune diseases have life threatening effect when not intervened properly, for an instance in myasthenia gravis.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
The mechanism of action on such therapy by far remains to be the most promising form treatment. Immune system suppression is not a new patient management or treatment for certain medical diseases, there have been several oral, parenteral or intravenous drugs were already made to achieve similar results. But some patients remain unresponsive.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.
The results concerning clodronate liposome therapy has been quite fascinating. It showed a strong performance in suppressing the immune system which gave a new hope for rejected transplant patients as well as those that have been suffering on the worst stage of their autoimmune disease. Additionally, such therapy also showed positive results in conjunction with cancer drugs.
Originally clodronic acid is biphosphonate, anti-osteoporotic drug. It was approved for the treatment and prevention of osteoporosis particularly to women and hyperparathyroidism, hypercalcemia and vertebral fracture to men. It was noticed that clodronic acid has a potent analgesic and anti inflammatory effects as it significantly reduced important inflammatory markers.
Inflammatory marker as the name implies is a sign that inflammation is currently going on. Famous inflammatory markers includes interleukin 6,8 and 1 as well as TNF-alfa. However, these markers are only a tiny part of the immune system. Indeed, the immune system consists of thousands of cells all of which has its own tiny role.
Clodronic acid liposome therapy, targets the macrophages to efficiently halt the attack of healthy cells. Suppressing your macrophages will slow down inflammation thus decreasing the pace of disease progression. Some autoimmune diseases have life threatening effect when not intervened properly, for an instance in myasthenia gravis.
More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.
The mechanism of action on such therapy by far remains to be the most promising form treatment. Immune system suppression is not a new patient management or treatment for certain medical diseases, there have been several oral, parenteral or intravenous drugs were already made to achieve similar results. But some patients remain unresponsive.
With the discovery of clodronic acid therapy, these possibilities may be the least of your concerns. Through the use of liposomes as the drug vehicle the main drug, clodronic acid will be delivered inside the macrophages and after exceeding its threshold, dies by apoptosis. Liposomes are easily engulfed by macrophages which makes it a great choice as a drug vehicle. As the drug is delivered directly into the phagocytic cells, there's a greater chance of suppressing the immune system.
The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.
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